U.S. successfully tested a new method of non-hormonal male contraception on monkeys-the rhesus monkey.
Scientists from the USA has successfully tested on monkeys-the rhesus monkey organic compound EP055, is able to reduce sperm motility. Based on this connection, researchers create a male contraceptive that does not affect the hormonal balance of the body. A study published in the journal PLOS ONE, says the Chronicle.info with reference to the Telegraph.
Today, there are only two “male” methods of contraception: condoms and vasectomy (ligation or removing fragments of VAS deferens). The first option is not always reliable, and the effect of the second in some cases is irreversible. To create an effective contraceptive for men trying to many researchers. For this purpose, synthetic analogues of some toxins, and also polymer plugs that block the VAS deferens. None of these funds has not yet entered the market.
The purpose of the new contraceptives — the protein EPPIN (epididymal protease inhibitor) on the surface of sperm. It’s one of the proteins that regulate the viscosity of semen and, consequently, sperm motility. Mobility of male germ cells largely determines the probability of conception, “slow” sperm are often the cause of male infertility. According to scientists, the deliberate slowing of sperm will help to create a contraceptive that does not affect the balance of hormones in the body. The existing prototype male hormonal contraceptives have many side effects such as mood swings, fluctuation in body weight, increase in the risk of depression.
In order to effectively lock the protein EPPIN, the researchers tried several derivatives of 1,3,5-triazines. These substances are widely used in chemistry, their compounds are included in dyes and fertilizers. Connection EP055 had the best solubility and half-life of the substance from the body: it is necessary that the contraceptive effect was reversible.
The substance is introduced intravenously to four male rhesus monkeys. After a few hours the sperm motility dropped significantly — this level is considered to be insufficient for conception. The movement began to grow only three days, and function fully recovered after 18 days. Side effects in animals not noted. Now researchers are working on a formula of tablets containing the required amount EP055. After this the researchers plan to conduct another series of tests.
In April of 2018 began a clinical trial of hormonal male contraceptive, in the tests involved about 400 pairs from different countries.